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The Mixed Lineage Leukemia gene (MLL) is altered in leukemia by chromosomal translocations to pro...

关键词: CRISPR screen    MLL    ZFP64    addiction    leukemia    motif    oncogene    promoter   
期刊:Cancer Cell  影响因子:23.916  发表日期: 20181210  PMID: 30503706 


Cyclin dependent kinase 4/6 (CDK4/6) inhibitors (CDK4/6i) are effective in breast cancer; however...

关键词: CDK4/6 inhibitors    FAT1    Hippo pathway    RB1    YAP    abemaciclib    breast cancer    drug resistance    palbociclib    ribociclib   
期刊:Cancer Cell  影响因子:23.916  发表日期: 20181210  PMID: 30537512 


Drug resistance represents a major challenge to achieving durable responses to cancer therapeutic...

期刊:Cancer Cell  影响因子:23.916  发表日期: 20181210  PMID: 30537514 


Identifying the earliest somatic changes in prostate cancer can give important insights into tumo...

期刊:Cancer Cell  影响因子:23.916  发表日期: 20181210  PMID: 30537516 


Multiple mechanisms of resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhi...

期刊:Cancer Cell  影响因子:23.916  发表日期: 20181210  PMID: 30537515 


Defects in apoptotic cell death can promote cancer and impair responses of malignant cells to ant...

关键词: BCL-2    BH3-mimetic drugs    BH3-only proteins    MCL-1    apoptosis    cancer   
期刊:Cancer Cell  影响因子:23.916  发表日期: 20181210  PMID: 30537511 


Members of the KDM5 histone H3 lysine 4 demethylase family are associated with therapeutic resist...

期刊:Cancer Cell  影响因子:23.916  发表日期: 20181210  PMID: 30472020 


Glucocorticoid resistance represents a major challenge in treating acute lymphoblastic leukemia. ...

关键词:   
期刊:Cancer Cell  影响因子:23.916  发表日期: 20181210  PMID: 30537507 


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