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Understanding the functional impact of genomic variants is a major goal of modern genetics and pe...

理解基因组变异的功能影响是现代遗传学和个体化医学的一个主要目标。尽管许多同义变异和非编码变异通过改变pre-mRNA剪接效率发挥作用,但是难以预测这些变异如何影响pre-mRNA剪接。这里,我们...

关键词: pre-mRNA    mRNA splicing    mRNA剪接   
期刊:Genome Biol  影响因子:14.028  发表日期: 20180601  PMID: 29859120 


BACKGROUND: The initiation of growth cessation and dormancy represent critical life-history trade...

期刊:Genome Biol  影响因子:14.028  发表日期: 20180604  PMID: 29866176 


Aberrant promoter methylation is a common mechanism for tumor suppressor inactivation in cancer. ...

期刊:Genome Biol  影响因子:14.028  发表日期: 20180605  PMID: 29871649 


We report a microfluidic system that physically separates nuclear RNA (nucRNA) and cytoplasmic RN...

关键词: Cytoplasm    Isotachophoresis    Microfluidics    Nucleus    RNA transport    RNA-seq    Single cell    Splicing   
期刊:Genome Biol  影响因子:14.028  发表日期: 20180606  PMID: 29871653 


BACKGROUND: Haloarchaea, a major group of archaea, are able to metabolize sugars and to live in o...

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期刊:Genome Biol  影响因子:14.028  发表日期: 20180607  PMID: 29880023 


We discuss a recent study that has identified and validated the link between a type-2 diabetes (T...

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期刊:Genome Biol  影响因子:14.028  发表日期: 20180607  PMID: 29880058 


There is an increased need for integrative analyses of multi-omic data. We present and benchmark ...

期刊:Genome Biol  影响因子:14.028  发表日期: 20180608  PMID: 29884221 


BACKGROUND: Pear (Pyrus) is a globally grown fruit, with thousands of cultivars in five domestica...

期刊:Genome Biol  影响因子:14.028  发表日期: 20180611  PMID: 29890997 


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