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The implementation of precision medicine requires the recruiting of patients in statistically eno...

期刊:Best Pract Res Clin Rheumatol  影响因子:0.0  发表日期: 20170601  PMID: 29224672 


关键词: CRV    HERNS    HVR    TREX1    V235fs    multiple sclerosis    pseudotumour    vasculitis   
期刊:J Neurol Neurosurg Psychiatry  影响因子:0.0  发表日期: 20170809  PMID: 28794152 


CTLA4 blockers have limited activity in patients with chemorefractory lung cancer. Recent clinica...

关键词: CGAS    STING    TREX1    ipilimumab    non-small cell lung carcinoma    type I interferon   
期刊:Oncoimmunology  影响因子:5.333  发表日期: 20190101  PMID: 31413913 


BACKGROUND: The study aimed to explore the correlation between the expression of?TREX1?and the me...

期刊:J Orthop Surg Res  影响因子:1.545  发表日期: 20161124  PMID: 27881153 


BACKGROUND: Mutations in the three-prime repair exonuclease 1 (TREX1) gene have been associated w...

关键词: DNase1    TREX1    Vasculopathy    brain ischemia    macrophages    microglia   
期刊:Brain Pathol  影响因子:6.155  发表日期: 20181101  PMID: 30062819 




The detection of intracellular DNA has emerged to be a key event in the innate immune response to...

关键词: AIM2    ASC    ATLD    ATM    Animals    Ataxia telangiectasia mutated    Autoimmunity    BMDC    BMDM    CARD    CT    DAI    DNA    DNA receptor    DNA virus    DNA-PKcs    DNA-dependent activator of IRFs    DNA-dependent protein kinase catalytic subunit    EBER    EBV    Epstein–Barr virus    Epstein–Barr virus encoded small RNA    Gene Expression    HFF    HMGB    HSV    HT    Humans    IFI16    IFN    IFNγ-inducibe protein 16    IL    IRF3    ISD    Immunity, Innate    Inflammation    Innate immunity    Interferon    Interferon Type I    MAPK    MAVS    MDA5    MDDC    MDM    MEF    MVA    Meiotic recombination 11    Modified Vaccinia Ankara    Mre11    NF-kB    PAMP    PBMC    PM    PRR    RIG-I    RIG-like receptor    RLR    RNA interference    RNAi    Receptors, Cell Surface    SLE    STING    SeV    Sendai virus    TANK-binding kinase    TBK1    TLR    TREX1    Toll-like receptor    VACV    VSV    Virus Diseases    Z-DNA binding protein    ZBP1    absent in melanoma 2    apoptosis-associated speck-like protein containing a CARD    ataxia-telangiectasia-like disorder cells    bone marrow-derived dendritic cells    bone marrow-derived macrophages    cGAMP    cGAS    calf thymus    caspase activation and recruitment domain    cyclic GMP-AMP    cyclic GMP-AMP synthase    double-stranded    ds    herpes simplex virus    herring testis    high mobility group box    human foreskin fibroblasts    immunostimulatory DNA    interferon    interferon regulatory factor    interleukin    melanoma differentiation factor 5    mitochondrial antiviral signalling    mitogen-activated protein kinase    monocyte-derived dendritic cells    monocyte-derived macrophages    mouse embryonic fibroblasts    nuclear factor kB    pathogen-associated molecular pattern    pattern recognition receptor    peripheral blood monocytic cells    peritoneal macrophages    retinoic acid-inducible gene    single-stranded    small nuclear RNA    snRNA    ss    stimulator of IFN genes    systemic lupus erythematosus    tRNA    three prime repair exonuclease 1    transfer RNA    vaccinia virus    vesicular stomatitis virus   
期刊:Immunobiology  影响因子:2.798  发表日期: 20131101  PMID: 23962476 


Type I interferon (IFN) is a critical mediator of autoimmune diseases such as systemic lupus eryt...

期刊:Eur J Immunol  影响因子:4.695  发表日期: 20180401  PMID: 29215161 


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